Immunomodulatory effect of macrolides: At what cost?
نویسندگان
چکیده
We present the case of a 60-year old female patient, with a 10 year history of non-CF bronchiectasis and use of macrolides as maintenance immunomodulatory treatment, who was diagnosed with macrolide-resistant Mycobacterium avium complex lung disease. Macrolides' immunomodulatory effect is appealing for non- CF bronchiectasis patients, hiding a high risk for resistance emergence.
منابع مشابه
Macrolides and respiratory infection in critically ill patients: what is the next step?
Several observational studies as well as experimental data suggest that the use of macrolides is associated with better outcomes in patients with severe pneumonia. In severe community acquired pneumonia (SCAP), data demonstrate a benefit of combination therapy, including a beta-lactam plus a macrolide or floroquinolone, at least in the subgroup of patients with critical disease. Such combinatio...
متن کاملImmunomodulatory and anti-inflammatory properties of macrolides
Macrolides are a group of antibiotics whose activity is ascribable to the presence of the macrolide ring, a large macrocyclic lactone ring, to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The most commonly used macrolides have 14 (e.g. erythromycin, clarithromycin, roxithromycin) or 15 (e.g. azithromycin) atoms attached to their macrocyclic ring and therefo...
متن کاملThe Immunomodulatory Effects of Macrolides—A Systematic Review of the Underlying Mechanisms
Background The mechanisms underlying the non-antimicrobial immunomodulatory properties of macrolides are not well understood. Objectives To systematically review the evidence for the immunomodulatory properties of macrolides in humans and to describe the underlying mechanism and extent of their influence on the innate and adaptive immune system. Methods A systematic literature search was do...
متن کاملImmunomodulatory properties of antibiotics.
There is growing evidence that certain antibiotics exert their beneficial effects not only by killing or inhibiting the growth of bacterial pathogens but also indirectly by immunomodulation. This review aims at giving an overview of the immunomodulatory properties of antibiotics in different diseases: The antiinflammatory properties of macrolides in chronic inflammatory pulmonary disorders were...
متن کاملImmunomodulatory effects of macrolides during community-acquired pneumonia: a literature review.
Macrolides are known to possess immunomodulatory properties, next to their antimicrobial effects. These immunomodulatory activities have been proven beneficial in chronic pulmonary inflammatory diseases. Whether macrolides also exert favourable immunomodulatory effects during acute inflammation, and therefore can act as adjuvant therapy in community-acquired pneumonia (CAP), is less clear. We a...
متن کامل